FUNPEP: Information system for "low complexity
sequence regions".
Copyright (C) 1999, FUNPEP.
The beta-2 microglobulin
Beta-2 microglubulin has crucial role in immunulogy. It is the small invariant
subunit of the highly polymorphic class I hitocompatibility (human HLA)
antigens which are located on the external surface membrane and within
all nucleated mammalian cells. Chronic kidney failure and the haemodialytic
procedure are associated with a high prevalence of a particular form of
amyloidosis, mainly involving the muscle-skeletal system, in which the
amyloid fibrils are composed of beta-2 microglobulin. The SWISSPROT sequences
are here,
the result of the multiple sequence alingment is here.
Gergo Kiss 30th March 1999
EMBL/Szeged