FUNPEP: Information system for "low complexity
sequence regions".
Copyright (C) 1999, FUNPEP.
The gelsolin protein
Gelsolin is a calcium regulated, actin-modulating protein that binds to
the plus (or barbed) ends of actin monomers or filaments, preventing monomer
exchange (end-blocking or capping). It can promote the assembly of monomers
into filaments (nucleation) as well as sever filaments already formed.
Gelsolin-related amyloidosis or familial amyloidosis, Finnish type (FAF)
is a hereditary amyloid disease caused by a mutation in a precursor protein
for amyloid (gelsolin) and characterized by corneal dystrophy and polyneuropathy.
Our SWISSPROT sequences are here,
the result of the multiple sequence alingment is here.
Gergo Kiss 2nd April 1999
EMBL/Szeged