FUNPEP: Information system for "low complexity
sequence regions".
Copyright (C) 1999, FUNPEP.
The lysozyme protein
Lysozyme is a ubiquitous bacteriolytic enzyme present in external secretions
and in polymorphs and macrophages, but its physicological role is not always
clear. Hereditary non-neuropathic systeic amyloidosis (Ostertag-type) is
rare autosomal disease in which amyloid deposition in the viscera is usually
fatal by the fifth decade. In some families it is caused by the mutations
of apoA-I,
but in other families amyloid deposits were formed by lysozyme. The natural
wild type of lysozyme is not amyloidogenic, but its two mutations, Ile56Thr
and Asp67His are able to form amyloid fibrils. Our sequences are here,
and teh result of the multiple sequence alignment is here.
Gergo Kiss 30th March 1999
EMBL/Szeged