Other information
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Introduction
The main interest of the BIOcomputing 3D modelling unit is understanding
proteins. How do they work? Why do they work? Why are they the way
they are? To get answers to these questions we like to collaborate with
experimental scientists. It is one thing to calculate something, but is
a whole other game to prove that the outcome of the calculation is
correct. Throughout these pages you will find many references to practical
work. Much of it in collaboration with colleagues at EMBL, but we also
collaborate with colleagues from elsewhere.
To understand proteins we use the program WHAT IF
to look at their 3D structures. Sometimes these structures can be obtained from
the PDB. More often, however, they have to
be modelled by homology. Most times, unfortunately, neither a structure nor somethings
that looks like it is available, and in those cases we will refer you to our
partners in the BIOcomputing unit.
Large parts of our efforts are directed towards improving the model building
by homology procedures and towards improving the detection of homology so that
more models can be build.
Topics for which information is or will be available
(C) G.V. 14-Mar-1998